The village of Ghizzano is located on a clayey high ground between the streams Roglio and Melogio, about 9 km from Peccioli. Findings from the nearby archaeological site in Santa Mustiola testify the presence of Romans and Longobards in the past.

Ghizzano is first mentioned in an archive document dating back to 988, where the presence of two farms is reported.

From the 10^th to the 13^th century, the town was owned by the diocese of Volterra and run by the counts Pannocchieschi, a period during which there is evidence of the presence of a castle.

Together with Peccioli, Lajatico and Legoli, the village was disputed between the Ghibelline League of Pisa and the Guelphs of Florence due to its strategic border position, until the castle of Ghizzano was returned to the Pisans in 1364.

In this period, the counts Venerosi from Strido acquired prestige in Ghizzano and settled in the highest part of the town, in the location of a stronghold, and transformed it into their residence.

We have news of the church of Saints Germano and Prospero since 1406, while the Oratory of Santissima Annunziata was built at the end of the 19^th century.

Today the town is a center of contemporary art thanks to the interventions of some artists of our time: David Tremlett, who saw the street via di Mezzo as a canvas and remodeled and colored its walls, Alicja Kwade, who created the sculpture SolidSky, and Patrick Tuttofuoco, who was inspired by Gozzoli for his Elevatio corpus.